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Translocations

What are translocations?

The term translocation is used when the location of specific chromosome material changes. There are two main types of translocations: reciprocal and Robertsonian. In a reciprocal translocation, two different chromosomes have exchanged segments with each other:

Genetic illustration demonstrating reciprocal translocation
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In a Robertsonian translocation, an entire chromosome attaches to another at the centromere:

Genetic illustration demonstrating Robertsonian translocation
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This newly formed chromosome is called the translocation chromosome. The translocation in this example is between chromosomes #14 and 21. When a baby is born with this type of translocation chromosome (between #14 and 21), in addition to one normal 14 and two normal 21 chromosomes, the baby will have Down syndrome. This is also called translocation Down syndrome.

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Online Resources of Medical Genetics


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