The All Children's Hospital Johns Hopkins Medicine Clinical and Translational Research Organization (CTRO) was established to facilitate clinical and translational research development in pediatrics with reach throughout the region, in Baltimore, and beyond.
The CTRO provides a centralized infrastructure to enhance and support the design, execution, and oversight of clinical and translational research, in fulfillment of the research mission at ACH JHM. This mission is to improve the health of children by providing patients and health care professionals with access to innovative research opportunities to advance the diagnosis, treatment and prevention of pediatric onset diseases and their adverse outcomes.
Annually ACH JHM conducts approximately 300 IRB-approved, active studies; over half of these are clinical trials. Nearly all prospective studies are now supported by CTRO personnel.
ACH JHM is the Clinical Coordinating Center for the KidsDOTT trial, a definitive multicenter randomized clinical trial to establish the duration of anticoagulation for venous thrombosis in children. This also includes Central Investigational Pharmacy and Central Biorepository roles.
In addition to the CTRO, ACH JHM has an independent pediatric Institutional Review Board that was established in the early 1980s. Effective Fall 2013, this IRB is one of the Johns Hopkins Medicine IRBs.
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