All Children’s has begun a clinical research trial of a surgical procedure that holds promise for treating neurogenic bladder in children with spina bifida or spinal cord injuries.
The three-year, blinded, IRB-approved study will involve children with spina bifida or spinal cord injuries. It began in mid-March with eight children who underwent surgery. Seven were spina bifida patients who were already undergoing surgery for spinal cord detethering; half also underwent the “Xiao procedure” that All Children’s physicians are evaluating. The eighth patient, whose bladder dysfunction was a result of surgery during his infancy to remove a spinal cord tumor, had surgery specifically to undergo the Xiao procedure.
The Xiao procedure was developed by Chuan-Guo Xiao, M.D., Chairman of the Department of Urology at Union Hospital, Tongji Medical College, People’s Republic of China. The Xiao procedure, developed during NIH-funded research in the U.S. and China, has been performed on some 1,500 adults and children in the People’s Republic. Pediatric urologist Yves Homsy, M.D. became interested in the procedure last year after meeting Professor Xiao at an International Children’s Continence Symposium in Hong Kong.
Dr. Homsy and pediatric neurosurgeons Gerald Tuite, M.D. and Luis Rodriguez, M.D., subsequently visited Professor Xiao to review his results and learn the technique. They are working together in the clinical research trial at ACH.
The Xiao procedure involves an intradural re-routing of lumbar to sacral nerves to provide a new pathway for voluntary bladder emptying. After the “skin-CNS-bladder” reinnervation procedure, the bladder and bowels are activated when the patient vigorously scratches a spot on the thigh. Following surgery, neurological healing and nerve regeneration take at least eight months.
About the Physicians
Dr. Yves Homsy, M.D.
Dr. Yves Homsy serves as Clinical Professor of Surgery (Urology) and Pediatrics at the University of South Florida, and practices as a Pediatric Urologist at All Children's Hospital.
Dr. Homsy attained his Medical Degree and completed an internship at Cairo University in Cairo, Egypt, and followed that with a Residency in General Surgery at Greek Community Hospital in Cairo. After moving to Canada, Dr. Homsy then completed another internship at Montreal General Hospital, followed by Residencies in General Surgery (Sainte‑Jeanne d'Arc Hospital, Montreal) and Urology (McGill University Urology Training Programme, Montreal and Toronto).
His career has included extensive research, teaching, and publishing. Dr. Homsy practiced and taught at the University of Montreal and McGill University before joining the University of South Florida and All Children's Hospital in 1995.
Dr. Luis Rodriguez
Dr. Luis Felipe Rodriguez practices Pediatric Neurosurgery at All Children's Hospital and the University of South Florida. He is Assistant Professor of Neurosurgery in the Department of Neurological Surgery and Rehabilitation, University of South Florida School of Medicine.
Upon receiving his medical degree at the University of Michigan, Dr. Rodruguez stayed on at the University of Michigan for a General Surgery Internship and Residency in Neurosurgery. Dr. Rodriguez completed his medical education with a Pediatric Neurosurgery Fellowship at the Primary Children's Medical Center, University of Utah Department of Neurosurgery , in Salt Lake City. Dr. Rodriguez joined the USF faculty in 2005. His primary neurosurgical focus is on spine issues in children.
Dr. Gerald Tuite, M.D.
After graduating from Medical School at Northwestern University Medical School in Chicago, Dr. Tuite completed his general surgery internship at Northwestern University and his Neurosurgery Residency at University of Michigan. After serving a year as Chief Resident at the University of Michigan, Dr. Tuite took a Pediatric Neurosurgical and Complex Spinal Fellowship at Great Ormond Street Hospital for Children in London, England. Dr. Tuite completed his medical training with a Pediatric Neurosurgery Fellowship at Texas Children's Hospital in Houston.
In 2008 Dr. Tuite re-joined the USF Neurosurgery Faculty and All Children's Hospital Pediatric Neurosurgery program after serving as Director of Pediatric Neurosurgery at the Medical University of South Carolina. In his years at the Medical University of South Carolina, Dr. Tuite also served as Neurosurgery Residency Program and was active in training residents and fellows.